![]() Anorexia has also been observed in some cats.Īlthough the symptoms of EPI are typical, they are not pathognomonic. Finally, malassimilation of nutrients (fats, carbohydrates, proteins, vitamins, trace elements), small intestinal bacterial overgrowth, morphologic and functional changes of small intestine are produced as a result of EPI.ĭogs and cats with EPI usually have a history and clinical signs of small bowel diarrhoea with voluminous, semiformed, yellowish or gray feces, polyphagia, pica especially in young dogs with inherited EPI, extreme weight loss, intestinal borborygmus, and dermatological problems such as poor coat and seborrhoea sicca. Therefore, a decrease of intraduodenal concentration of pancreatic enzymes, bicarbonate, antibacterial and enteric mucosal "trophic" factors, as well as pancreatic and GI regulatory peptides are observed. Eurytrema procyonis flukes attached in the pancreatic ducts have been reported as a cause of EPI in some cats.ĮPI is characterized by loss of the majority of the functional reserve capacity of the exocrine pancreas. In cats chronic pancreatitis is the most common cause of EPI. Chronic pancreatitis, repeated episodes of acute or subacute pancreatitis and pancreatic neoplasia are also reported as a cause of canine EPI. Although PAA has been reported in many breeds, a familiar predisposition exists in German Shepherd dogs, collies and English setters. The etiopathogenesis of PAA has not yet been determined. The most common cause of EPI in dogs is pancreatic acinar atrophy (PAA). ![]() Exocrine Pancreatic Insufficiency (EPI) is a syndrome that is characterized by a lack of effective pancreatic exocrine secretion in the small intestine.ĮPI is not a rare clinical condition in both dogs and cats.
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